Voters legalized the drug for medical use in 2008, but there have been conflicts in the courts.
Legislation up for a vote today in the Republican-controlled House would create a tiered regulatory system.
A state license would be required to grow, process, sell, transport and test marijuana.
Dispensaries would pay a 3 percent tax on their gross retail income.
More than 211,000 qualifying patients now grow their own marijuana plants or obtain the drug from registered caregivers under the 2008 law.